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Synthroid (levothyroxine) 125 mg, may be taken with or without food.
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|Pregnancy category||US: A (No risk in human studies)|
|Routes of administration||by mouth, intravenous|
|ATC code||H03AA01 ( WHO )|
|Legal status||US: ℞-only|
|Metabolism||mainly in liver, kidneys, brain and muscles|
|Elimination half-life||ca. 7 days (in hyperthyroidism 3–4 days, in hypothyroidism 9–10 days)|
|Excretion||feces and urine|
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Service types included inpatient admissions, emergency department visits, outpatient visits, outpatient laboratories, and outpatient prescriptions. If a switch occurs, thyroid-stimulating hormone laboratory values should be monitored postswitch to ensure that levels remain consistent with appropriate treatment.
Diagnosis was not restricted to a particular service setting, allowing both inpatient and outpatient claims to be used to select patients. Utilization and expenditure variables were created separately for the synthroid price philippines and postperiods.
In the brand-to-generic switch group, however, most index dates were in and Utilization and expenditures specific to hypothyroidism also were tallied separately to determine if hypothyroidism was a driver of total costs. Synthroid price philippines were tabulated and compared using chi-square and t-tests to assess for differences between cohorts.
Patients were stratified into continuous users and switchers.
Utilization and expenditure variables were created separately for the pre- and postperiods. The percentage of continuous users and switchers with utilization of specific service types was calculated. Across all cohorts, the most common hypothyroidism diagnosis was ICD-9 code
Print yourself http://thesquall.com/propecia/propecia-cost-in-india instant PS Card now. Levothyroxine design should sometimes be used in the content of rezept responsible or good thyroxine unless this hormone is associated with use.
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The distribution of index dates within each matched group was similar since index dates were assigned to continuous users as part of the matching process. The study period for all patients included a 6-month preperiod and a 6-month postperiod.
The US Food and Drug Administration FDA considers generic formulations meeting bioequivalence standards to be therapeutically equivalent to the specific brand-name drug used as a reference comparator. Claims are de-identified, so the use of the database for research purposes complies with HIPAA requirements and does not require institutional review board oversight. For continuous users, index dates were assigned during the matching process, such that the distribution of index dates by quarter and year would be similar for each matched group.
The primary outcome of interest was postswitch expenditures. Any date on which the patient had a levothyroxine drug claim was eligible for assignment as the index date, provided there were at least 6 months of stable-dose continuous use of the drug before and after the index date.
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Inpatient and outpatient services with a primary first diagnosis of hypothyroidism ICD-9 code Across generic synthroid price cohorts, the most common hypothyroidism diagnosis was ICD-9 code sources The study period for all patients included a 6-month preperiod and a 6-month postperiod. Study inclusion required at least 1 claim carrying a hypothyroidism diagnosis congenital hypothyroidism, International Statistical Classification of Diseases, Ninth Revision [ICD-9] code
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Healthcare Costs Associated with Switching from Brand to Generic Levothyroxine
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Although of primary importance to payers, healthcare costs are increasingly important to patients, who typically bear a portion of the costs, 13 as well as to providers, who may be under pressure to minimize costs. The mean daily dose of levothyroxine was calculated from the tablet strength, quantity dispensed, and days supply information on drug claims.
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- The presence of 8 comorbidities—depression, hyperlipidemia, atherosclerosis, angina, hypertension, myocardial infarction, stroke, and arrhythmia—was also assessed, based on the relevant diagnosis codes in the pre-index claims data
- In the brand-to-generic switch group, however, most index dates were in and
- Results A total of 97, continuous users, 10, brand-to-brand switchers, 21, brand-to-generic switchers, and multiple switchers met all study inclusion and exclusion criteria
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- Finally, patients without mental health benefits were excluded, because their available claims may not represent their complete utilization
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The distribution of index dates within each matched group was similar since index dates were assigned to continuous users cost for depo provera part of the matching process. Subsequent to matching drug users, brand-to-brand switchers, brand-to-generic switchers, multiple switchers, and an synthroid price philippines number of corresponding continuous users for each switch subgroup remained.
Although of primary importance to payers, healthcare costs are increasingly important to patients, who typically bear a portion of the costs, 13 as well as to providers, who may be under pressure to minimize costs.
The percentage of continuous users and switchers with utilization of specific service types was calculated. XX, or acquired hypothyroidism, ICD-9 code The demographic characteristics of the study population, by matched cohort, are presented in Table 1.
Switchers who could not be closely matched to a continuous user were dropped from the sample. Inpatient and outpatient services with a primary first diagnosis of hypothyroidism ICD-9 code XX, or acquired hypothyroidism, ICD-9 code
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|Finally||Never||The blood organizations that bonded with the doctor medicines are synthroid 75 mcg price internalized in the face order||Variables were tabulated and compared using chi-square and t-tests to assess for differences between cohorts|
|Switchers who could not be closely matched to a continuous user were dropped from the sample||Any date on which the patient had a levothyroxine drug claim was eligible for assignment as the index date||Variables were tabulated and compared using chi-square and t-tests to assess for differences between cohorts||Controversy exists|
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Several exclusion criteria were applied to help ensure a homogeneous sample. XX sometime during the available claims history.
The mean daily dose of levothyroxine was calculated from the tablet strength, quantity dispensed, and days supply information on drug claims. Synthroid 75 mcg price expenditures were calculated using all patients in the cohort as the denominator.
Switchers without at least 6 months of stable-dose levothyroxine therapy postindex were dropped. Results A total of 97, continuous users, 10, brand-to-brand switchers, 21, brand-to-generic switchers, and multiple switchers met all study inclusion and exclusion criteria.
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In the multiple-switch group, where nearly three fourths of all first switches were to a generic drug, the index dates also fell primarily in and XX, or acquired hypothyroidism, ICD-9 code Patients who subsequently switched to another levothyroxine formulation and could be followed for 6 months postswitch were matched to demographically similar patients who were continuous users of branded levothyroxine.
Switchers without at least synthroid generic price months of stable-dose levothyroxine therapy postindex were dropped.
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Finally, patients without mental health benefits were excluded, because their available claims may not represent their complete utilization. In the brand-to-generic switch group, however, most index dates were in and
The primary outcome of interest was postswitch expenditures. The multiple-switch group was screened to exclude patients who were quick switchers, defined as having a second switch within 14 days of the first switch.
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These matched switcher-continuous user pairs comprised the final study population included in this analysis see the Appendix online at www.
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